Method for recovering myeloperoxidase and pharmaceutical composition containing myeloperoxidase as major constituent
AssigneeThe Green Cross Corporation
InventorsEichi Hasegawa, Takashi Kobayashi
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Abstract
Myeloperoxidase can be separated and recovered from a supernatant liquid of an aqueous dispersion of a disintegration product of human myelogenous leukocytes, which dispersion has been admixed with at least one member selected from the group consisting of manganese salts and protamine sulfate. The recovered myeloperoxidase in combination with an alkali metal halide can be used as a pharmaceutical composition effective against microorganisms deficient or diminished in catalase synthesizing activity.
Claims12
A pharmaceutical composition effective against tubercle bacillus resistant to isonicotinic acid hydrazide deficient or diminished in catalase synthesizing activity, consisting essentially of 5 to 0.05 m moles of a pharmacologically acceptable alkali metal halide for 100 to 0.05 units of a myeloperoxidase originated from human myelogenous leukocytes.
Dependencies are inferred from the claim text.