Esters of arylpropionic acids endowed with an anti-inflammatory activity
AssigneeAusonia Farmaceutici s.r.l.
InventorsPaolo Ferruti, Ferdinando Danusso, Maria C. Tanzi, Giuseppe Quadro
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Abstract
The present invention concerns tetraethylene glycol monoesters with 2-arylpropionic acids (known as anti-inflammatory agents). Said esters, while being endowed with the characteristics of low toxicity and gastric injuring effects shown by the related acids, differ advantageously from the latter because their anti-inflammatory activity is much more prolonged, and their bioavailability markedly better.
Claims7
The tetraethylene glycol monoester with 2-(4-isobutyl-phenyl) propionic acid.
Tetraethylene glycol monoester with 2-[4-(2-thenoyl)phenyl]propionic acid.
Tetraethylene glycol monoester with 2-[4-(1-oxo-2-isoindolinyl)phenyl]propionic acid.
Tetraethylene glycol monoester with 2-(3-benzoyl-phenyl) propionic acid.
Tetraethylene glycol monoester with 2-(3-fluoro-4-phenyl-phenyl) propionic acid.
Tetraethylene glycol monoester with 2-(6-methoxy-2-naphthyl) propionic acid.
A pharmaceutical composition endowed with an anti-inflammatory and analgesic activity, which contains as the active ingredient, at least one ester, which is 2-(4-isobutyl-phenyl) propionic acid, 2-[4-(2-thenoyl)phenyl]propionic acid, 2-[4-(1-oxo-2-isoindolinyl)phenyl]propionic acid, 2-(3-benzoyl-phenyl) propionic acid, 2-(3-fluoro-4-phenyl-phenyl) propionic acid, or 2-(6-methoxy-2-naphthyl) propionic acid, in the form of a racemic or of an enantiomer.
Dependencies are inferred from the claim text.