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US 4,379,090 AGranted
Process for the preparation of 1-(phenyl and halophenyl)-3,4-dihydro-4-[(dimethylamino)methylene]5H-2-benzazepin-5-on e-2-oxides
AssigneeHoffmann-La Roche Inc.
InventorEugene J. Trybulski
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Abstract
Compounds of the formula ##STR1## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activity. Also disclosed are other intermediates and processes for their production.
Claims1
A process to produce a compound of the formula ##STR6## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, which consists essentially of:
- (a) reacting a compound of the formula ##STR7## wherein X and Y are as above, with a peracid in an inert organic solvent at from about 0.degree. C. to 40.degree. C. and separating the analogous N-oxide thereof and
- (b) thereafter reacting the N-oxide of step (a) with dimethylformamide dimethylacetal in an inert solvent at from about 0.degree. C. to 100.degree. C. to produce the end product.
Dependencies are inferred from the claim text.