Heat stabilization of plasma proteins
AssigneeAmerican National Red Cross
InventorsCraigenne A. Williams, Milan Wickerhauser
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Abstract
A method for the heat stabilization of a plasma protein such as C1-INA or Factor IX comprising heating the protein in an aqueous medium in the presence of potassium or ammonium citrate in an amount of from in excess of 2.0 M to saturation of the medium. The method is particularly applicable to the stabilization of plasma proteins against thermal denaturation during pasteurization.
Claims10
A method for the heat stabilization of a plasma protein comprising heating the protein in an aqueous medium in the presence of ammonium or potassium citrate in an amount in excess of 2.0 M to saturation of the aqueous medium.
A method for the pasteurization of a plasma concentrate of a plasma protein comprising pasteurizing the plasma concentrate in the presence of ammonium or potassium citrate in an amount of from in excess of 2.0 M to saturation of the concentrate.
A method for the preparation of a pasteurized plasma concentrate of C1-INA or Factor IX comprising partially purifying a C1-INA or Factor IX plasma fraction, concentrating the partially purified product, and pasteurizing the resultant concentrate in the presence of ammonium or potassium citrate in an amount of from in excess of 2.0 M to saturation of the concentrate.
Dependencies are inferred from the claim text.