Process for preparing a physiologically active substance controlled release composite composition

A process for preparing a physiologically active substance controlled release composite composition which comprises the steps of:

• using a physiologically active substance-containing adsorbent prepared by adsorbing a first physiologically active substance onto an inorganic adsorbent;
• dispersing and mixing a second physiologically active substance, which is different from said first physiologically active substance, onto said physiologically active substance containing adsorbent;
• dispersing the resulting mixture in a polymerizable vinyl monomer containing 0-50% of a synthetic high molecular weight substance which is polymerizable at a temperature of below -20.degree. C.;
• and
• after holding the desired shape, irradiating the resulting dispersion with an ionizing radiation at a temperature within the range of -20.degree. to -100.degree. C. to polymerize.