Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
AssigneeThomas Jefferson University
InventorJewell L. Osterholm
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Abstract
A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.
Claims7
An apparatus for treating hypoxic-ischemic neurologic tissue, comprising:
- (a) a reservoir containing synthetic oxygenatable nutrient liquid for treating hypoxic-ischemic neurologic tissue;
- (b) oxygenator means for oxygenating said liquid, to produce an oxygenated liquid;
- (c) cerebrospinal injection means for injecting said oxygenated liquid into an extra-vascular cerebrospinal body pathway;
- and
- (d) cerebrospinal withdrawal means for withdrawing fluid from said extra-vascular cerebrospinal pathway to create, in combination with said injection means, a circulation of said oxygenated liquid within said cerebrospinal pathway.
Dependencies are inferred from the claim text.