Pharmaceutical compositions
AssigneeSmith Kline & French Laboratories Limited
InventorsGraham J. Durant, Charon R. Ganellin, Margaret R. Vickers
Life of this patent
Estimating the term…
Abstract
S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
Claims11
A pharmaceutical composition having immunosuppressant activity comprising a pharmaceutical carrier and, in an effective amount to produce immunosuppressant activity, an isothiourea derivative of the formula:
- ##STR3## wherein n is 2, R.sup.1 and R.sup.2 together with the nitrogen atom shown form a piperidine ring;
- and R.sup.3 and R.sup.4, which may be the same or different, are lower alkyl, or together may form a --(CH.sub.2).sub.x --group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
A method of producing immunosuppressant activity by administering to an animal in need thereof an effective amount of an isothiourea of the formula:
- ##STR4## wherein n is 2, R.sup.1 and R.sup.2 together with the nitrogen atom shown form a piperidine R.sup.3 and R.sup.4, which may be the same or different, are lower alkyl, or together may form a --(CH.sub.2).sub.x --group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
A method of treating rheumatoid arthritis by administering to an animal in need thereof an effective amount of an isothiourea derivative of the formula:
- ##STR5## wherein n is 2, 3 or 4;
- R.sup.1 and R.sup.2 together with the nitrogen atom shown form a piperidine, ring;
- and R.sup.3 and R.sup.4, which may be the same or different, are lower alkyl, or together may form a --(CH.sub.2).sub.x --group where x is 2;
- or a pharmaceutically acceptable acid addition salt thereof.
A method of treating psoriasis by administering to an animal in need thereof a therapeutically effective amount of an isothiourea of the formula:
- ##STR6## wherein n is 2, 3 or 4;
- R.sup.1 and R.sup.2 together with the nitrogen atom shown form a piperidine ring;
- and R.sup.3 and R.sup.4, which may be the same or different, are lower alkyl, or together may form a --(CH.sub.2).sub.x --group where x is 2, or a pharmaceutically acceptable acid addition salt thereof.
A method of reducing inflammation by administering to an animal in need thereof a therapeutically effective amount of an isothiourea of the formula:
- ##STR7## wherein n is 2, 3 or 4;
- R.sup.1 and R.sup.2 together with the nitrogen atom shown form a piperidine ring;
- and R.sup.3 and R.sup.4 ;
- which may be the same or different, are lower alkyl, or together may form a --(CH.sub.2).sub.x --group where x is 2, or a pharmaceutically acceptable acid addition salt thereof.
An isothiourea derivative of the Formula:
- ##STR8## wherein n is 2, 3 or 4;
- R.sup.1 and R.sup.2 together with the nitrogen atom shown form a piperidine ring;
- and R.sup.3 and R.sup.4, which may be the same or different, are lower alkyl, or together may form a --(CH.sub.2).sub.x --group wherein x is 2;
- or a pharmaceutically acceptable acid addition salt thereof.
Dependencies are inferred from the claim text.