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US 4,378,362 AGranted
Indolizine derivatives and process for preparing the same
AssigneeLabaz
InventorsGilbert Rosseels, Henri Inion
Life of this patent
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AssigneeLabaz
InventorsGilbert Rosseels, Henri Inion
Estimating the term…
Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups, X.sub.1 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy, A represents a group selected from: ##STR2## in which X.sub.2 represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X.sub.3 represents hydrogen, chlorine, bromine, iodine or methyl, R.sub.1 represents a methyl, ethyl, n-propyl or n-butyl radical, n represents an integer in the range of 2 to 6 inclusive, with the proviso that when both X.sub.2 and X.sub.3 represent hydrogen or methyl, X.sub.1 is other than hydrogen. They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrhythmias.
An indolizine compound corresponding to the formula:
1-Bromo-2-methyl-3-[4-(3-di-n-butylamin opropyl)-oxy-3-bromo-benzoyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
2-n-Butyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3-bromo-benzoyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
2-Ethyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3-chloro-benzoyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
2-n-Butyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3-chloro-benz oyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
2-Isopropyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3,5-dichloro-benzoyl]-ind olizine and pharmaceutically acceptable acid addition salts thereof.
1-Bromo-2-phenyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3-chloro-benz oyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
1-Chloro-2-ethyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3-chloro-benzoyl]-in dolizine and pharmaceutically acceptable acid addition salts thereof.
1-Chloro-2-n-butyl-3-[4-(3-di-n-butylaminopropyl]-oxy-benzoyl]-in dolizine and pharmaceutically acceptable acid addition salts thereof.
1-Bromo-2-(4-chloro-phenyl)-3-[4-(3-di-n-butylaminopropyl)-oxy-3- chloro-benzoyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
1-Bromo-2-n-b utyl-3-[4-(3-di-n-butylaminopropyl)-oxy-3-chlorobenzoyl]-indolizine and pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.