Theophyllinylmethyldioxolane derivatives, methods for their preparation and pharmaceutical compositions containing them
AssigneesIstituto Biologico Chemioterapico "ABC" S.p.A., Unibios S.p.A
InventorsUgo Chiodoni, Jose S. Franzone, Silvano Spinelli
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Abstract
Compounds of the following general formula ##STR1## wherein: X and Y are different from each other and represent --CH.sub.2 -- or an oxygen atom; R represents a radical selected from hydroxy, bromo, acetoxy, pyrrolidino, morpholino, piperazino and piperazino substituted at the position 4 by a carbethoxy, benzyl, phenyl, halophenyl, methoxyphenyl or trifluoromethylphenyl group, or when X is --CH.sub.2 -- and Y is an oxygen atom, R may represent also chloro; methods for their preparation; pharmaceutical compositions containing them. The compounds possess a remarkable antitussive activity.
Claims12
Theophyllinylmethyldioxolane derivatives of the following general formula ##STR7## wherein:
- X and Y are different from each other and represent --CH.sub.2 -- or an oxygen atom;
- R represents a radical selected from hydroxy, bromo, acetoxy, pyrrolidino, morpholino, piperazino and piperazino substituted at the position 4 by a carbethoxy, benzyl, phenyl, halophenyl, methoxyphenyl or trifluoromethylphenyl group;
- or when X is --CH.sub.2 -- and Y is an oxygen atom, R may also represent chloro.
Dependencies are inferred from the claim text.