Novel C-076 compounds
AssigneeMerck & Co., Inc.
InventorsRobert T. Goegelman, Vincent P. Gullo, Louis Kaplan
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Abstract
There are disclosed certain new compounds related to C-076 compounds which have been produced by a mutant of the culture that produced the original C-076 compounds and isolated from the fermentation broth thereof. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached thereto are considerably modified from the original C-076 compounds. The new compounds have been found to retain the biological activity of the parent C-076 compounds. The compounds are thus potent antiparasitic agents and compositions and methods for such uses are also disclosed.
Claims11
A compound having the formula ##STR5## wherein:
- (a.) R.sub.1 is .alpha.-L-oleandrosyl;
- R.sub.2 is sec-butyl;
- and R.sub.3 is methyl;
- (b.) R.sub.1 is .alpha.-L-oleandrosyl;
- R.sub.2 is sec-butyl;
- and R.sub.3 is hydrogen;
- and
- (c.) R.sub.1 is .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyl;
- R.sub.2 is sec-butyl and R.sub.3 is hydrogen.
A compound having the formula:
- ##STR6## wherein:
- (a.) R.sub.2 is isopropyl;
- and R.sub.3 is methoxy;
- (b.) R.sub.2 is sec-butyl;
- and R.sub.3 is keto;
- and
- (c.) R.sub.2 is iso-propyl;
- and R.sub.3 is keto.
A compound having the formula:
- ##STR7## wherein R.sub.1 is .alpha.-L-oleandrosyl-.alpha.-L-oleandrosyl;
- R.sub.2 is sec-butyl;
- and R.sub.3 is hydrogen.
Dependencies are inferred from the claim text.