.omega.-(2-Oxo-benzazolinyl)-alkanoic acid derivatives
AssigneeA. Nattermann & Cie GmbH
InventorsHans-Heiner Lautenschlager, Hans Betzing, Brigitte Stoll, Manfred Probst
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Abstract
The present invention refers to new .omega.-(2-oxo-benzazolinyl)-alkanoic acids as well as salts and esters thereof having the general formula I ##STR1## and having antiinflammatory, analgesic and antithrombotic activity.
Claims15
.omega.-(2-Oxo-benzazolinyl)-alkanoic acids of formula I ##STR5## wherein m is an integer ranging from 6 to 10
- R.sup.1 is hydrogen, an alkali metal ion or a straight or branched hydrocarbon group having from 1 to 6 carbon atoms,
- X is a NR.sup.3 -group, R.sup.3 representing --H, --(CH.sub.2).sub.n --R.sup.4 with n being an integer from 0 to 7 and R.sup.4 being a methyl group, the unsubstituted phenyl group or the substituted phenyl group ##STR6## R.sup.2 and R.sup.5 which may be identical or different from each other, represent hydrogen, halogen, a methyl, a trifluoromethyl, a methoxy, a nitro or an amino group.
8-(2-Oxo-benzimidazolin-1-yl)-caprylic acid and their pharmacologically compatible salts and esters.
8-(3-Octyl-2-oxo-benzimidazolin-1-yl)-caprylic acid and their pharmacologically compatible salts and esters.
7-(2-Oxo-3-phenyl-benzamidazolin-1-yl)-enanthic acid and their pharmacologically compatible salts and esters.
8-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-caprylic acid and their pharmacologically compatible salts and esters.
11-(2-Oxo-3-phenyl-benzimidazolin-1-yl)-undecanoic acid and their pharmacologically compatible salts and esters.
7-[3-(3-Chlorophenyl)-2-oxo-benzimidazolin-1-yl]-enanthic acid and their pharmacologically compatible salts and esters.
8-[3-(3-Chlorophenyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and ester.
8-(3-Benzyl-2-oxo-benzimidazolin-1-yl)-caprylic acid and their pharmacologically compatible salts and esters.
8-[3-(2-Chlorobenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and esters.
8-[3-(4-Chlorobenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and esters.
8-[3-(4-Fluorobenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and esters.
8-[3-(4-Methylbenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and esters.
8-[2-Oxo-3-(3-trifluoromethylbenzyl)-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and esters.
8-[3-(4-Methoxybenzyl)-2-oxo-benzimidazolin-1-yl]-caprylic acid and their pharmacologically compatible salts and esters.
Dependencies are inferred from the claim text.