Derivative of 4-(N-(substituted-benzylidene)amino-methyl cyclohexane-1-carboxylic acid
AssigneeKureha Kagaku Kogyo Kabushiki Kaisha
InventorsHitoshi Takita, Yutaka Mukaida, Sakuo Noda, Hidetoshi Kobayashi
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Abstract
A novel compound of 4-[N-(substituted-benzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a salt or an ester thereof which has specific pharmacologic activities, a method for preparing thereof and a pharmaceutical composition comprising thereof as an active ingredient are provided.
Claims13
A compound represented by the formula (I):
- ##STR4## wherein X is hydroxyl- or methoxy group,
- Y is hydrogen or hydroxyl or methoxy group,
- m and n are positive integers and the sum of m and n is equal to or less than 5,
- or a pharmaceutically acceptable salt thereof selected from the group consisting of sodium-, potassium-, calcium-, magnesium-, primary ammonium-, secondary ammonium-, tertiary ammonium- and quarternary ammonium salts or a pharmaceutically acceptable alkyl ester thereof having 1 to 3 carbon atoms in said alkyl group, provided that 4-[N-(3',4'-dihydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid is not included in the formula (I).
Trans-4-[N-(2'-hydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a sodium salt thereof.
Trans-4-[N-(4'-hydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid.
Tra ns-4-[N-(2',3'-dihydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a sodium salt thereof.
Trans-4-[N-(2',4'-dihydroxyb enzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a sodium salt thereof.
Trans-4-[N-(2'-methoxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a sodium salt thereof.
Trans-4-[N-(3',4'-dimethoxy benzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a sodium salt thereof.
Trans -4-[N-(2',3',4'-trimethoxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid or a sodium salt thereof.
Trans-4-[N-(3'-methoxy-4'-h ydroxybenzylidene)aminomethyl]cyclohexane-1-carboxylic acid.
Dependencies are inferred from the claim text.