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US 4,377,589 AGranted
Substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols
AssigneeAmerican Cyanamid Company
InventorsAndrew S. Tomcufcik, William B. Wright, Jr., Joseph W. Marsico, Jr.
Life of this patent
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Abstract
This disclosure describes substituted 2-alkylimino-3-alkyl-4-benzhydryl-4-thiazolidinols which are useful as diuretic agents.
Claims8
A compound selected from the group consisting of the formula:
- ##STR7## wherein R.sub.1 is hydrogen, fluoro or chloro, R.sub.2 is hydrogen, fluoro or chloro R.sub.3 is alkyl having up to 4 carbon atoms, and R.sub.4 is alkyl having up to 4 carbon atoms;
- and the pharmacologically acceptable acid-addition salts thereof.
The method of inducing diuresis in a mammal which comprises administering to said mammal a diuretic effective amount of a compound of the formula:
- ##STR8## wherein R.sub.1 and R.sub.2 may be the same or different and are hydrogen, fluoro or chloro and R.sub.3 and R.sub.4 may be the same or different and are alkyl having up to 4 carbon atoms;
- or the pharmaceutically acceptable acid-addition salts thereof.
Dependencies are inferred from the claim text.