4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
AssigneesMerck Sharp & Dohme (I.A.) Corp., Merck & Co., Inc.
InventorsEdward J. Cragoe, Jr., Clarence S. Rooney, Haydn W. R. Williams
Life of this patent
Estimating the term…
Abstract
Novel 4-(substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate renal lithiasis.
Claims7
The compounds having the structure:
- ##STR6## wherein n is 0 to 2, the dotted line indicates saturation or unsaturation or pharmaceutically acceptable salts thereof with the proviso that the substituents on the thiazolyl ring are not adjacent.
A method of treating persons afflicted with with calcium oxalate renal lithiasis or preventing the formation of calcium oxalate kidney or bladder stones which comprises administration to such patients an effective amount of compound having the structure:
- ##STR9## wherein n is 0 to 2, the dotted line indicates saturation or unsaturation or pharmaceutically acceptable salts thereof with the proviso that the substituents on the thiazolyl ring are not adjacent.
A method of treating persons afflicted with calcium oxalate renal lithiasis or preventing the formation of calcium oxalate kidney or bladder stones which comprises administration to such patients an effective amount of compound having the structure:
- ##STR10##
Dependencies are inferred from the claim text.