A compound of the formula ##STR153## wherein Y.sup.1 is chloro, Y.sup.2 is OR and Y.sup.3 is hydrogen or OR and the pharmaceutically acceptable acid addition salts thereof;
- R is alkyl having from one to three carbon atoms;
- R.sup.1 and R.sup.2 are the same or different and when taken separately are each a member selected from the group consisting of hydrogen, alkyl having from 1 to 5 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms;
- alkenyl having from 3 to 5 carbon atoms, alkynyl having from 3 to 5 carbon atoms, hydroxy substituted alkyl having from 2 to 5 carbon atoms and when taken together with the nitrogen atom to which they are attached R.sup.1 and R.sup.2 form ##STR154## where X.sup.1 is a member selected from the group consisting of S(O).sub.t, CHOR.sup.6, --(CH.sub.2).sub.p -- and CHR.sup.7, and X.sup.2 is a member selected from the group consisting of X.sup.1, O, NR.sup.3, NCOR.sup.4 and NCOOR.sup.5, where
- m is 2 or 3,
- n is 2 or 3,
- p is 1 to 3,
- t is 0, 1 or 2;
- R.sup.3 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl from 3 to 5 carbon atoms, alkynyl having from 3 to 5 carbon atoms, hydroxy substituted alkyl having from 2 to 5 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, --(CH.sub.2).sub.q C.sub.6 H.sub.4 R.sub.8 and --(CH.sub.2).sub.q C.sub.10 H.sub.6 R.sup.8, where q is 0 or 1;
- R.sup.4 is a member selected from the group consisting of hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 3 to 5 carbon atoms, cycloalkyl and cycloalkylmethyl wherein said cycloalkyl has from 3 to 8 carbon atoms, ##STR155## R.sup.10, CH.sub.2 R.sup.10 and (CH.sub.2).sub.q C.sub.6 H.sub.4 R.sup.8 where A is S or O, q is as defined above and R.sup.10 is a member selected from the group consisting of ##STR156## where r is 1 or 2;
- R.sup.5 is a member selected from the group consisting of alkyl having from 1 to 7 carbon atoms, alkenyl having 3 to 5 carbon atoms, cycloalkyl having from 3 to 8 carbon atoms, hydroxy substituted alkyl having from 2 to 5 carbon atoms, CH.sub.2 C.sub.6 H.sub.4 R.sup.8, CH.sub.2 C.sub.10 H.sub.6 R.sup.8, CH.sub.2 R.sup.10 and CH.sub.2 O-pyridyl;
- R.sup.6 is a member selected from the group consisting of hydrogen, C.sub.6 H.sub.4 R.sup.8, --(CH.sub.2).sub.p Z R.sup.15, alkyl having from 1 to 6 carbon atoms and said alkyl substituted by a member selected from the group consisting of Cl, F, Br, OH, CH.sub.3 O, SO.sub.2 CH.sub.3 and NHSO.sub.2 CH.sub.3, where p and A are as previously defined and Z is a member selected from the group consisting of O, S, SO, SO.sub.2, and NR.sup.16 ;
- R.sup.7 is a member selected from the group consisting of alkyl having from one to six carbon atoms, hydroxyalkyl having from one to five carbon atoms, --(CH.sub.2).sub.q C.sub.6 H.sub.4 R.sup.8 and COC.sub.6 H.sub.4 R.sup.8 ;
- R.sup.8 is a member selected from the group consisting of H, Cl, Br, F, CH.sub.3, CH.sub.3 O, CF.sub.3, OH, SO.sub.2 CH.sub.3 and NHSO.sub.2 CH.sub.3 ;
- R.sup.9 is a member selected from the group consisting of H, Cl, CH.sub.3, C.sub.2 H.sub.5 and phenyl;
- R.sup.11 is hydrogen or methylthio and
- R.sup.12 is a member selected from the group consisting of H, NH.sub.2 alkyl having from one to four carbon atoms and NHCO.sub.2 R.sup.14 ;
- R.sup.14 is alkyl having from one to four carbon atoms;
- R.sup.15 is a member selected from the group consisting of alkyl having from one to four carbon atoms, C.sub.6 H.sub.4 R.sup.8 and C.sub.10 H.sub.6 R.sup.8 ;
- and R.sup.16 is hydrogen or alkyl having from one to four carbon atoms.