Tricyclic quinazoline derivatives
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsIkuo Ueda, Masayuki Kato, Masanobu Nagano
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Abstract
Quinazoline derivatives of the formulae: ##STR1## wherein A.sup.1 is ##STR2## A.sup.2 is ##STR3## R.sup.1 is hydrogen, carboxy or esterified carboxy, R.sub.a.sup.1 and R.sub.b.sup.1 are esterified carboxy, R.sup.2 and R.sup.3 are hydrogen, alkyl, halogen, nitro, amino, alkoxy, aryloxy, alkylthio, alkylpiperazinyl, acylamino or dialkylamino which may be substituted with hydroxy, R.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy, dialkylamino or 2,2-dialkoxycarbonylvinylamino R.sub.a.sup.4 is hydrogen, alkyl, hydroxy, alkoxy, alkenyloxy or dialkylamino, R.sup.5 is alkyl or alkenyl, and R.sup.6 is carboxy or esterified carboxy.
Claims10
A pyrimidoquinazoline compound of the formula:
- ##STR35## wherein A.sup.2 is a group of the formula:
- ##STR36## R.sup.1 is hydrogen, carboxy or C.sub.2 -C.sub.7 alkoxycarbonyl, R.sup.2 and R.sup.3 are hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, nitro amino, C.sub.1 -C.sub.6 alkoxy, phenyloxy, C.sub.1 -C.sub.6 alkylthio, C.sub.1 -C.sub.6 alkylpiperazinyl, C.sub.1 -C.sub.18 alkanoylamino, di(C.sub.1 -C.sub.6)alkanoylamino, C.sub.3 -C.sub.9 alkoxalylamino, C.sub.4 -C.sub.8 cycloalkanecarbonylamino, C.sub.3 -C.sub.7 cycloalkyl(C.sub.1 -C.sub.6)alkanoylamino, benzamido, phenyl(C.sub.1 -C.sub.6)alkanoylamino, C.sub.1 -C.sub.6 alkanesulfonylamino or di(C.sub.1 -C.sub.6)alkylamino which may be substituted with hydroxy,
- R.sup.4 is hydrogen, C.sub.1 -C.sub.6 alkyl, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkenyloxy or di(C.sub.1 -C.sub.6)alkylamino, and
- R.sup.5 is C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkenyl, or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.