US 4,377,533 A · Process for introducing alkyl radicals into carbon chains having a functional group and compounds prepared by said process

Abstract

Process for introducing a substituent selected from branched- or straight-chain alkyl radicals having from 1 to 12 carbon atoms, aralkyl or cycloalkyl radicals in which the alkyl moiety has from 1 to 4 carbon atoms, into a carbon chain bearing a stable functional group the said carbon chain having at least one proton in .alpha.-position in relation to this functional group, process whereby, in a first step, this carbon chain is reacted with a complex base comprising a mixture of alkali metal amide and alkali metal alcoholate suspended in an anhydrous organic solvent to provide temporarily a carbanion, then in a second step this carbanion is reacted in an anhydrous organic solvent with an alkyl, aralkyl or cycloalkyl halide corresponding to the substituent to be introduced.

Claims8

Dependent claims

Process for preparing a nitrile of general formula:

##STR7## in which R represents hydrogen or n-propyl, whereby n-propyl bromide and a nitrile of the formula:
##STR8## in which R and R.sub.1, which are the same or different, represent hydrogen or n-propyl, are placed in contact, both reactants being in the same anhydrous medium selected from benzene, toluene, cyclohexane, diisopropyl ether, tetrahydrofuran or a mixture of such solvents, at a temperature between -10.degree. and +45.degree. C., with a mixture composed of 2 parts of a sodium amide to 1 part of a sodium alcoholate, the latter being selected from sodium n-propylate, sodium isopropylate, sodium t-butylate and sodium 2-ethoxyethylate, and the resulting propylated nitrile separated from the reaction mixture.

Dependencies are inferred from the claim text.

Facts

Application

06/250,852Filed 3 Apr 1981 · continuation in part

Priority

FR 79 300397 Dec 1979

Granted

22 Mar 1983

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 255/00
Carboxylic acid nitriles
C07C 51/353
By reactions not involving formation of carboxyl groups: by isomerisation; by change of size of the carbon skeleton
C07C 53/126
Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen: acids containing more than four carbon atoms
C07C 253/30
Preparation of carboxylic acid nitriles: by reactions not involving the formation of cyano groups

Process for introducing alkyl radicals into carbon chains having a functional group and compounds prepared by said process

Life of this patent

Process for introducing alkyl radicals into carbon chains having a functional group and compounds prepared by said process

Life of this patent

Abstract

Claims8