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US 4,377,531 AGranted
Method for the alkylation of phenylacetonitriles
AssigneeAmerican Cyanamid Company
InventorCharles P. Grasso
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Abstract
A method for the alkylation of certain substituted phenylacetonitriles with alkylhalides in the presence of solid particulated alkali metal hydroxides under essentially anhydrous conditions. Trialkylamine catalysts may optionally be utilized. Compounds obtained by this method, some of which are valuable intermediates in the preparation of pyrethroid pesticides, are described.
Claims10
A method for the preparation of compounds of structural formula:
- ##STR6## wherein Z is C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.3 alkoxy or halogen;
- R.sub.1 is C.sub.1 -C.sub.4 alkyl;
- comprising reacting one mole of a compound of the structural formula:
- ##STR7## with from one to four moles of a compound of formula R.sub.1 -X, wherein Z and R.sub.1 are as defined above and X is halogen, in the presence of from one to five moles of solid particulated potassium or sodium hydroxide at a temperature from 20.degree. to 100.degree. C. or at the reflux temperature of the mixture, until the reaction is essentially complete.
1 more element
Dependencies are inferred from the claim text.