Method of purifying eicosapentaenoic acid and its esters
AssigneeNippon Suisan Kaisha, Ltd.
InventorsTakao Fujita, Masahiro Makuta
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Abstract
A method of purifying eicosapentaenoic acid and esters of eicosapentaenoic acid comprising subjecting a mixture containing eicosapentaenoic acid or an ester of eicosapentaenoic acid to the following steps in either order: (1) urea treatment, where the treatment comprises contacting the mixture with a polar organic solvent containing dissolved urea whereby a solution containing the acid or ester is formed, precipitating urea crystals from the solution, and removing the urea crystals, and (2) fractional distillation.
Claims14
A method of purifying eicosapentaenoic acid and esters of eicosapentaenoic acid, comprising:
- treating a mixture containing eicosapentaenoic acid or an ester of eicosapentaenoic acid with urea, wherein said treating comprises contacting said mixture with a polar organic solvent and urea so that a solution containing said acid or ester and urea is formed, precipitating urea crystals from said solution, and removing said crystals from said solution;
- and
- fractionally distilling said mixture.
Dependencies are inferred from the claim text.