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US 4,376,781 AGranted
Pharmaceutical compositions
AssigneeInverni Della Beffa S.p.A.
InventorsAndrea Lietti, Attilio Bonati
Life of this patent
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Abstract
Valuable pharmaceutical properties of flavylium salts are described, including anti-inflammatory, vaso-protective, hypolipaemic, hypocholesterolaemic and hypoglycaemic activity. The use of flavylium salts as drugs and the production of pharmaceutical compositions containing them is particularly referred to.
Claims22
A pharmaceutical composition comprising,
- as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure
- A.sup.+ --B X.sup.-
- containing at least one hydroxy or methoxy substituent and wherein A.sup.+ is selected from the group consisting of ##STR15## B is selected from the group consisting of ##STR16## and X.sup.- is a pharmaceutically acceptable anion, and a pharmaceutically acceptable diluent or carrier, with the proviso that where the composition consists of a solution of said flavylium salt, said solution also contains at least one pharmaceutically acceptable additive selected from the group consisting of preservatives and buffering, thickening, suspending, stabilizing, wetting, emulsifying, coloring and flavoring agents.
A pharmaceutical composition comprising,
- as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure
- A.sup.+ --B X.sup.-
- containing at least one hydroxy or methoxy substituent and wherein A.sup.+ is selected from the group consisting of ##STR17## B is selected from the group consisting of ##STR18## and X.sup.- is a pharmaceutically acceptable anion, and a pharmaceutically acceptable diluent or carrier selected from the group consisting of carboxy vinyl polymers, propylene glycol, cetyl alcohol, saturated vegetable triglycerides, fatty acid esters, triethanol amine, glycerol, starch, sorbitol, bentonite, carboxymethyl cellulose, lauryl sulfate, dicalcium phosphate, powdered silica, and lecithin.
A pharmaceutical composition comprising,
- as active ingredient, a cicatrizing, epithelium-regenerating, anti-inflammatory, vaso-protective, hypolipemic, hypocholesterolemic or hypoglycemic response elliciting quantity of a flavylium salt of the structure
- A.sup.+ --B X.sup.-
- containing at least one hydroxy or methoxy substituent and wherein A.sup.+ is selected from the group consisting of ##STR19## B is selected from the group consisting of ##STR20## and X.sup.- is a pharmaceutically acceptable anion, and a combination of at least two different pharmaceutically acceptable diluents or carriers.
Dependencies are inferred from the claim text.