Thiazolidine derivatives use
AssigneeTakeda Chemical Industries, Ltd.
InventorsYutaka Kawamatsu, Takashi Sohda, Takeo Hirata
Life of this patent
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Abstract
A thiazolidine derivative of the formula: ##STR1## wherein R.sub.1 is hydrogen, hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms, or lower carboxylic acyloxy having 2 to 4 carbon atoms; each of R.sub.2 and R.sub.3 is hydroxyl, lower alkyl having 1 to 4 carbon atoms, lower alkoxy having 1 to 4 carbon atoms or lower carboxylic acyloxy having 2 to 4 carbon atoms or pharmaceutically acceptable salt thereof a is a novel compound having antiulcer activity and inhibitory effect on gastric acid secretion. The compound is useful as antiulcer agent or inhibitory agent of gastric acid secretion.
Claims19
A thiazolidine compound of the formula:
- ##STR9## wherein R.sub.1 is hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and
- each of R.sub.2 and R.sub.3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
A method for treatment of a mammal suffering from an ulcer, which comprises administering to said mammal an effective amount of a thiazolidine compound of the formula:
- ##STR10## wherein R.sub.1 is hydrogen, hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and
- each of R.sub.2 and R.sub.3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms,
- or a pharmaceutically acceptable salt thereof.
A medicinal composition for the treatment of a mammal suffering from an ulcer, which comprises:
- (A) as an active ingredient, an effective amount of a thiazolidine compound of the formula:
- ##STR11## wherein R.sub.1 is hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms, and
- each of R.sub.2 and R.sub.3 is hydroxyl, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, or carboxylic acyloxy having 2 to 4 carbon atoms,
- or a pharmaceutically acceptable salt thereof, and
- (B) a physiologically acceptable carrier, excipient or diluent therefor.
Dependencies are inferred from the claim text.