N-[4-(4-Pyridinyl)phenyl]ureas and their cardiotonic use
AssigneeSterling Drug Inc.
InventorsGeorge Y. Lesher, Donald F. Page
Life of this patent
Estimating the term…
Abstract
Disclosed and claimed are N-R-N-40 [4-(4-2-R.sub.2 -3-R.sub.3 -5-R.sub.5 -6-R.sub.6 -4-pyridinyl)phenyl]ureas (I) or pharmaceutically-acceptable acid-addition salts thereof, where R is hydrogen, methyl or ethyl, R.sub.2 is hydrogen, methyl, ethyl or hydroxyl, R.sub.6 hydrogen, methyl or ethyl, and R.sub.3 and R.sub.5 are each hydrogen or methyl, their cardiotonic use and their preparation.
Claims12
A cardiotonic composition for increasing cardiac contractility, said composition comprising a pharmaceutically-acceptable inert carrier and, as the active component thereof, a cardiotonically-effective amount of N-R-N'-[4-(2-R.sub.2 -3-R.sub.3 -5-R.sub.5 -6-R.sub.6 -4-pyridinyl)phenyl]urea having the formula ##STR2## where R is hydrogen, methyl or ethyl, R.sub.2 is hydrogen, methyl, ethyl or hydroxyl, R.sub.6 is hydrogen, methyl or ethyl, R.sub.3 and R.sub.5 are each hydrogen or methyl, or pharmaceutically-acceptable acid-addition salt thereof.
The method for increasing cardiac contractility in a patient requiring such treatment which comprises administering orally or parenterally in a solid or liquid dosage form to such patient a cardiotonically-effective amount of N-R-N'-[4-2-R.sub.2 -3-R.sub.3 -5-R.sub.5 -6-R.sub.6 -4-pyridinyl)phenyl]urea having the formula ##STR3## where R is hydrogen, methyl or ethyl, R.sub.2 is hydrogen, methyl, ethyl or hydroxyl, R.sub.6 is hydrogen, methyl or ethyl, R.sub.3 and R.sub.5 are each hydrogen or methyl, or pharmaceutically-acceptable acid-addition salt thereof.
An N-R-N'-[4-(2-R.sub.2 -3-5 R.sub.5 -6-R.sub.6 -4-pyridinyl)phenyl]urea having the formula ##STR4## where R is hydrogen, methyl or ethyl, R.sub.2 is hydrogen, methyl, ethyl or hydroxyl, R.sub.6 is hydrogen, methyl or ethyl, R.sub.3 and R.sub.5 are each hydrogen or methyl, or pharmaceutically-acceptable acid-addition salt thereof.
N-[4-(4-pyridinyl)phenyl]urea or pharmaceutically-acceptable acid-addition salt thereof.
N-methyl-N'-[4-(4-pyridinyl)phenyl]urea or pharmaceutically-acceptable acid-addition salt thereof.
Dependencies are inferred from the claim text.