10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo-[a,d]-cycloheptenes, their preparation, and therapeutic agents containing these compounds
AssigneeBASF SE
InventorsGerd Steiner, Hans P. Hofmann, Horst Kreiskott, Hans-Juergen Teschendorf
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Abstract
10-Substituted 5-cyanomethylene-10,11-dihydro-dibenzo[a,d]-cycloheptenes, their pharmaceutically tolerated addition salts with acids, processes for their preparation, and their use as drugs, especially as sedatives, hypnotics or tranquilizers.
Claims10
A 10-substituted 5-cyanomethylene-10,11-dihydro-dibenzo[a,d]-cyclopheptene of the formula I ##STR8## where R.sup.1 and R.sup.2 are hydrogen, halogen, alkyl of 1 to 3 carbon atoms or trifluoromethyl, and A is piperazinyl, homopiperazinyl, piperidinyl or morpholinyl, an additional nitrogen atom being unsubstituted or substituted by alkyl of 1 to 3 carbon atoms, hydroxyalkyl of 2 or 3 carbon atoms, alkoxyalkyl, the alkoxy and alkyl radical each being of 1 to 3 carbon atoms, cycloalkyl or cycloalkylmethyl, of 3 to 7 carbon atoms in the cycloalkyl ring, or alkynyl of 2 to 5 carbon atoms and being additionally, where appropriate, substituted by oxygen in the form of an N-oxide, and its physiologically tolerated addition salts with acids.
cis,trans-5-Cyanomethylene-10-(4-methyl-piperazin-1-yl)-10,1 1-dihydro-dibenzo[a,d]-cycloheptene.
cis,trans-5-Cyanomethylene-10-(4- methyl-4-oxypiperazin-1-yl)-10,11-dihydro-dibenzo[a,d]-cycloheptene.
cis,trans-5-Cyanomethylene-10-(4-.beta.-hydroxyethyl-piperazin-1- yl)-10,11-dihydro-dibenzo[a,d]-cycloheptene.
cis,trans-5-Cyanomethylene-10-(4-ethyl-pi perazin-1-yl)-10,11-dihydro-dibenzo[a,d]-cycloheptene.
cis,trans-5-Cyanomethylene-2-chloro-10-(4-methyl-pi perazin-1-yl)-10,11-dihydro-dibenzo[a,d]-cycloheptene.
cis,trans-5-Cyanomethylene-10-(N'-methyl-homopipera zin-1-yl)-10,11-dihydro-dibenzo[a,d]-cycloheptene.
Dependencies are inferred from the claim text.