Use of piperazinyl-imidazo[1,2-a]pyrazines in sedation
AssigneeMerck & Co., Inc.
InventorsWalfred S. Saari, Joel R. Huff
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Abstract
Piperazinyl-imidazo[1,2-a]pyrazines and their acid addition salts are selective .alpha..sub.2 -adrenergic receptor antagonists and are thereby useful for treating sedation caused by antihypertensive drug therapy.
Claims7
A method of treating sedation caused by antihypertensive drug therapy through stimulation of presynaptic .alpha..sub.2 -adrenergic receptors in a patient in need of such treatment which comprises the administration of 0.01-20 mg/kg/day of a compound of structural formula:
- ##STR5## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or halogen;
- and R.sup.4 is hydrogen or C.sub.1-3 alkyl.
A pharmaceutical composition for treating hypertension and sedation caused thereby which comprises a pharmaceutical carrier, an effective amount of an antihypertensive agent known to cause sedation through stimulation of presynaptic .alpha..sub.2 -adrenergic receptors and an amount of a compound to provide a dosage of 0.01-20 mg/kg/day wherein the compounds has structural formula:
- ##STR6## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or halogen;
- and R.sup.4 is hydrogen or C.sub.1-3 alkyl.
Dependencies are inferred from the claim text.