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US 4,376,769 AGranted
Substituted imidazo thiazoles thiazines, thiazepines and thiazocines
AssigneeSchering Corporation
InventorSherlock Margaret H.
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Abstract
Disclosed herein are novel tetrahydro imidazo thiazoles, tetrahydro imidazo thiazines, hexahydro imidazo thiazepines and hexahydro imidazo thiazocines, intermediates for the preparation thereof, methods of using the compounds as anti-inflammatory agents and methods of using an intermediate thereof as anti-secretory agents to relieve the symptoms of gastric distress.
Claims15
Compounds of the formula ##STR8## and the non-toxic therapeutically effective acid addition and quatenary salts thereof wherein R and R' are independently hydrogen and lower alkyl;
- R" and R'" independently are members of the group consisting of hydrogen, lower alkyl, aryl, aralkyl, pyridyl, furyl, thienyl, benzhydryl, naphthyl, indolyl, biphenyl and indenyl, including X and/or Y substituted aryl, aralkyl, pyridyl, furyl, thienyl, benzhydryl, naphthyl, indolyl, biphenyl and indenyl wherein X and Y are members of the group consisting of halogen, hydroxy, nitro, amino, lower alkyl, lower alkoxy, trifluoromethyl, imidazolyl, trifluoromethylthio, lower alkylthio, lower alkyl sulfinyl and lower alkyl sulfonyl;
- n is an integer of 1 to 4;
- with the proviso that when n is 1 R" and R'" are not hydrogen or lower alkyl and when n=2 at least one of R" and R'" cannot be hydrogen;
- and with the further proviso that when n is 1, R" and R'" are not both phenyl at the 6-position of the imidazoline moiety.
1 more element
Dependencies are inferred from the claim text.