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US 4,376,765 AGranted
Medicaments, their preparation and compositions containing same
AssigneeInstitut International de Pathologie Cellulaire et Moleculaire
InventorsAndre B. L. Trouet, Michele M. L. G. Masquelier, Roger M. Baurain
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Abstract
The invention relates to a new pharmaceutical form of a medicament of the formula Carrier-Spacer arm-Drug in which "Drug" represents an active principle provided with a free amino function "Spacer arm" represents a peptidic chain of the X-L-Leu type and "Carrier" is a proteinic macromolecule adapted to the drug.
Claims13
A medicament compound of the formula
- Carrier-spacer arm-Drug
- wherein
- "drug" represents the therepeutically active principle containing a free amino function, said drug being selected from the group consisting of antitumoral anthracyclines, antimalarial and antileishmanial quinoleines,
- "spacer arm" is a chain of peptidic nature represented by the sequence
- X--L--Leu
- wherein L--Leu represents a L--leucyl moiety bound through its carboxylic amino function to the amino function of the drug and X represents 1, 2 or 3 aminoacids which may be identical or different, selected from the group consisting of L-alanine, glycine and L--leucine and having a possible succinylated terminal amino function, and --"carrier" is a macromolecule of proteinic nature, the nature of which is related to the transport and/or affinity of action intended for the drug, said carrier being selected from the group consisting of bovine serum albumin, fetuine, immuno-globuline, asiafetuine or peptidic hormones.
3 more elements
Dependencies are inferred from the claim text.