Process for the production of 4-aminobutyramide hydrochloride
AssigneeDegussa AG
InventorsKlaus Deller, Axel Kleemann, Jurgen Martens, Horst Weigel
Life of this patent
Estimating the term…
Abstract
4-aminobutyramide hydrochloride is produced by saponifying 4-(benzylamino)-or-4-(dibenzylamino)-butyronitrile to the corresponding substituted 4-aminobutyramide and subjecting this in the form of the hydrochloride in the presence of an inert solvent and a platinum metal catalyst to a hydrogenation treatment whereby the benzyl group or the two benzyl groups are split off.
Claims17
A process for the production of 4-aminobutyramide comprising (a) saponifying a substituted butyronitrile of the formula ##STR3## in which R is hydrogen or a benzyl group, or an acid addition salt thereof to the corresponding butyramide of the formula ##STR4## or an acid addition salt thereof, (b) if the butyramide of formula (II) is not in the form of the hydrochloride converting it to the hydrochloride, and (c) subjecting the hydrochloride of the butyramide of formula (II) in the presence of an inert solvent and a platinum group metal catalyst to hydrogenation.
A process for the production of 4-aminobutyramide hydrochloride comprising hydrogenating the hydrochloride of a butyramide of the formula ##STR5## where R is hydrogen or a benzyl group in the presence of an inert solvent and a platinum group metal catalyst.
Dependencies are inferred from the claim text.