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US 4,376,207 AGranted
Chiral synthesis of amino sugars
AssigneeHoffmann-La Roche Inc.
InventorsMilan R. Uskokovic, Peter M. Wovkulich
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Abstract
A simple and economic chiral synthesis of optically active methyl L-acosaminide and methyl L-daunosaminide from propenyl acetate, said methyl L-acosaminide and methyl L-daunosaminide being coupling agents for the production of known antitumor agents.
Claims4
A compound of the formula:
- ##STR16## wherein R is lower alkyl;
- R.sub.1 is OR.sub.2 or ///OH;
- and R.sub.2 is hydrogen, phenylsulfonyloxy, lower alkyl-substituted phenylsulfonyloxy, or lower alkylsulfonyloxy or enantiomers or racemic mixtures thereof.
Dependencies are inferred from the claim text.