Process for the preparation of indoles from anilines and ethanolamines
AssigneeMitsui Toatsu Chemicals, Inc.
InventorsFujio Matsuda, Takazo Kato
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Abstract
A process for the preparation of indole and derivatives thereof wherein an aniline is reacted with an ethanolamine in the vapor phase, the liquid phase or a mixed vapor-liquid phase. Various solid acids, metals and activated carbon can be used as catalysts for this reaction. The present invention makes it possible to prepare indole and derivatives thereof in a single step by using inexpensive compounds as the starting materials.
Claims11
A process for the preparation of an indole which comprises the step of contacting an aniline selected from the group consisting of aniline, o-toluidine, m-toluidine, p-toluidine, o-haloaniline, m-haloaniline, p-haloaniline, o-aminophenol, m-aminophenol, p-aminophenol, o-anisidine, m-anisidine and p-anisidine with an ethanolamine selected from the group consisting of monoethanolamine, diethanolamine and triethanolamine in the presence of a solid acid catalyst, in the vapor phase at a temperature of from 200.degree. to 600.degree. C., or in the liquid phase or a mixed vapor-liquid phase at a temperature of from 200.degree. to 500.degree. C.
Dependencies are inferred from the claim text.