# US 4,376,094 A · Method of disinfecting and a method for destroying bacteria and fungi using 2-substituted glutaraldehydes > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 4,376,094 A - Document ID: US4376094A - Status: Granted - Kind: A - Application number: 06/294,892 - Filed: 1981-08-21 - Granted: 1983-03-08 - Earliest claimed: 1980-08-30 - Assignees: Sterling Drug Inc. - Inventors: Wolfgang Munzenmaier; Heinz Eggensperger; Helmut H. Ehlers; Wolfgang Beilfuss; Lothar Bucklers; Hans-Peter Harke - Web page: https://patentgrep.com/patent/US4376094A ## CPC - A01N 35/02: containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals - C07C 45/60: in six-membered rings - C07C 47/21: with only carbon-to-carbon double bonds as unsaturation - C07C 47/225: containing rings other than six-membered aromatic rings - C07C 47/232: having unsaturation outside the aromatic rings - C07C 47/277: containing ether groups, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] groups - C07D 309/10: Oxygen atoms - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS - C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08) ## Abstract Disclosed is a method of disinfecting and a method for destroying bacteria and fungi employing certain 2-substituted glutaraldehydes having the formulas ##STR1## wherein R.sup.1 is selected from the group consisting of alkyl having from one to twelve carbon atoms, lower-alkoxyalkyl having from two to twelve carbon atoms, cycloalkyl having from three to twelve ring carbon atoms, and alkyl-substituted cycloalkyl having from three to eight ring carbon atoms and a total of from four to ten carbon atoms, and R.sup.3 is alkyl having from one to four carbon atoms. ## Claims ### Claim 1 A method for disinfecting an inanimate surface contaminated with deleterious microorganisms which comprises contacting said surface with an amount effective for disinfection thereof of a glutaraldehyde represented by the formulas ##STR4## wherein R.sup.1 is selected from the group consisting of alkyl having from one to twelve carbon atoms, lower-alkoxyalkyl having from two to twelve carbon atoms, cycloalkyl having from three to twelve ring carbon atoms, and alkyl-substituted cycloalkyl having from three to eight ring carbon atoms and a total of from four to ten carbon atoms, and R.sup.3 is alkyl having from one to four carbon atoms. ### Claim 2 (depends on 1) A method according to claim 1 wherein R.sup.1 is selected from the group consisting of alkyl having from one to eight carbon atoms, lower-alkoxyalkyl having from two to four carbon atoms, cycloalkyl having from three to seven ring carbon atoms and alkyl-substituted cycloalkyl having from three to seven ring carbon atoms and a total of from four to ten carbon atoms. ### Claim 3 (depends on 2) A method according to claim 2 wherein said cycloalkyl is cyclohexyl or alkyl-substituted cyclohexyl having a total of from seven to ten carbon atoms. ### Claim 4 (depends on 3) A method according to claim 3 wherein R.sup.3 is methyl or ethyl. ### Claim 5 (depends on 4) A method according to claim 4 wherein the glutaraldehyde is 2-(1-ethoxybutyl)glutaraldehyde. ### Claim 6 (depends on 3) A method according to claim 3 wherein the glutaraldehyde is represented by the formula ##STR5## ### Claim 7 (depends on 6) A method according to claim 6 wherein the glutaraldehyde is selected from the group consisting of 2-ethylideneglutaraldehyde, 2-butylideneglutaraldehyde, 2-(2-methylpropylidene)glutaraldehyde, 2-hexylideneglutaraldehyde, 2-(2-ethylhexylidene)glutaraldehyde, 2-octylideneglutaraldehyde and 2-(cyclohexylmethylene)glutaraldehyde. ### Claim 8 (depends on 6) A method according to claim 6 wherein the glutaraldehyde is 2-(2-methoxyethylidene)glutaraldehyde. ### Claim 9 (depends on 2) A method according to claim 2 wherein the glutaraldehyde is represented by the formula ##STR6## ### Claim 10 (depends on 1) A method according to claim 1 wherein the glutaraldehyde is represented by the formula ##STR7## ### Claim 11 A method for destroying bacteria and fungi which comprises applying to them or to an environment inhabited by them a bactericidally and fungicidally effective amount of a glutaraldehyde represented by the formulas ##STR8## wherein R.sup.1 is selected from the froup consisting of alkyl having from one to twelve carbon atoms, lower-alkoxyalkyl having from two to twelve carbon atoms, cycloalkyl having from three to twelve ring carbon atoms, and alkyl-substituted cycloalkyl having from three to eight ring carbon atoms and a total of from four to ten carbon atoms, and R.sup.3 is alkyl having from one to four carbon atoms. ### Claim 12 (depends on 11) A method according to claim 11 wherein R.sup.1 is selected from the group consisting of alkyl having from one to eight carbon atoms, lower-alkoxyalkyl having from two to four carbon atoms, cycloalkyl having from three to seven ring carbon atoms and alkyl-substituted cycloalkyl having from three to seven ring carbon atoms and a total of from four to ten carbon atoms. ### Claim 13 (depends on 12) A method according to claim 12 wherein said cycloalkyl is cyclohexyl or alkyl-substituted cyclohexyl having a total of from seven to ten carbon atoms. ### Claim 14 (depends on 13) A method according to claim 13 wherein the glutaraldehyde is represented by the formula ##STR9## ### Claim 15 (depends on 14) A method according to claim 14 wherein the glutaraldehyde is selected from the group consisting of 2-ethylideneglutaraldehyde, 2-butylideneglutaraldehyde, 2-(2-methylpropylidene)glutaraldehyde, 2-hexylideneglutaraldehyde, 2-(2-ethylhexylidene)glutaraldehyde, 2-octylideneglutaraldehyde and 2-(cyclohexylmethylene)glutaraldehyde. ### Claim 16 (depends on 14) A method according to claim 14 wherein the glutaraldehyde is 2-(2-methoxyethylidene)glutaraldehyde. ### Claim 17 (depends on 12) A method according to claim 12 wherein the glutaraldehyde is represented by the formula ##STR10## ### Claim 18 (depends on 13) A method according to claim 13 wherein R.sup.3 is methyl or ethyl. ### Claim 19 (depends on 18) A method according to claim 18 wherein the glutaraldehyde is 2-(1-ethoxybutyl)glutaraldehyde. ### Claim 20 (depends on 11) A method according to claim 11 wherein the glutaraldehyde is represented by the formula ##STR11##