Bis-esters of 1,1-alkanediols with 6-beta-hydroxymethylpenicillanic acid 1,1-dioxide
AssigneePfizer Inc.
InventorMichael S. Kellogg
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Abstract
Bis-Esters of 1,1-alkanediols with 6-beta(hydroxymethyl)penicillanic acid 1,1-dioxide and 6-betaacylaminopenicillanic acids are useful as antibacterial agents. Intermediates useful for the preparation of these compounds include halomethyl, alkylsulfonyloxymethyl and arylsulfonyloxymethylesters of 6-beta(hydroxymethyl)penicillanic acid 1,1-dioxide and 6-beta-aminopenicillanoyloxymethyl-6'-beta-(hydroxymethyl)penicillanate 1,1-dioxide.
Claims10
A compound of the formula ##STR14## wherein R' is hydrogen or methyl.
A compound of the formula ##STR15## wherein n is zero or an integer of value 1 or 2;
- R' is hydrogen or methyl;
- and X is chloro, bromo, iodo, (C.sub.1 -C.sub.4)alkylsulfonyloxy, benzenesulfonyloxy or toluenesulfonyloxy.
A compound of the formula ##STR16## wherein R' is hydrogen or methyl and X is chloro, bromo, iodo, (C.sub.1 -C.sub.4)alkylsulfonyloxy, benzenesulfonyloxy or toluenesulfonyloxy.
Dependencies are inferred from the claim text.