Back to results
US 4,375,545 AGranted
Process for the synthesis of the nicotinyl ester of 6-aminonicotinic acid
AssigneeWestwood Pharmaceuticals, Inc.
InventorsPaul L. Warner, Jr., Edward J. Luber, Jr., William A. Somerville, F. Christopher Zusi
Life of this patent
Estimating the term…
Abstract
6-Aminonicotinic acid is reacted with an alkali carbonate selected from the group consisting of sodium carbonate and potassium carbonate. The reaction is carried out at elevated temperature and in dimethylformamide. The 6-aminonicotinic acid alkali salt so produced is reacted with 3-chloromethylpyridine hydrochloride. The reaction is carried out at elevated temperature and in dimethylformamide. The desired nicotinyl ester is thus produced.
Claims4
A process for producing 6-aminonicotinic acid nicotinyl ester comprising the steps of
- (a) reacting 6-aminonicotinic acid with an equimolar amount of sodium carbonate, in dimethylformamide and at an elevated temperature, to produce the corresponding sodium salt of 6-aminonicotinic acid;
- (b) then, reacting said salt with 3-chloromethylpyridine hydrochloride in dimethylformamide and at an elevated temperature, to produce said nicotinyl ester.
Dependencies are inferred from the claim text.