Fused pyridines
AssigneeCroda Synthetic Chemicals Limited
InventorsOtto Meth-Cohn, Brahma Narine
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Abstract
Aromatic-.alpha.-halo-{b} fused pyridines are made by reacting an aromatic acetamide, acid halide and amide in particular proportions, with the acid halide always in excess. The process permits the production of compounds having a wide range of substituents, that are new compounds, and that are of value as intermediates in the synthesis of, for instance, pharmaceutical compounds.
Claims14
In the synthesis of an aromatic-.alpha.-halo[b]fused pyridine by reacting an N-substituted acetamide with an N-substituted formamide and an inorganic acid halide in a solvent, wherein the substituent on the N atom of the acetamide is an aromatic ring in which the ring carbon atom adjacent to the ring carbon atom substituted by the N atom is unsubstituted or is substituted by a labile substituent and wherein the carbon atom adjacent the CO group of the acetamide group carries at least two hydrogen atoms, the improvement consisting of reacting the acid halide in an amount of at least 2 moles per mole acetamide group and at least 1.5 moles per mole N-substituted formamide.
Dependencies are inferred from the claim text.