Fluorinated methyl beta-alanine derivatives
AssigneeMerrell Toraude et Compagnie
InventorsPhilippe Bey, Michael Jung, Fritz Gerhart
Life of this patent
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Abstract
Beta-monofluoromethyl beta-alanine, beta-difluoromethyl beta-alanine and pharmaceutically acceptable esters and amides derived from the acid group, amides derived from the amine group, and salts thereof are novel compounds which inhibit .gamma.-aminobutyric acid transaminase (GABA-T).
Claims9
3-amino-3-fluoromethylpropionic acid or a pharmaceutically acceptable salt thereof.
3-amino-3-difluoromethylpropionic acid or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition for use in increasing brain levels of GABA comprising an effective amount of 3-amino-3-fluoromethylpropionic acid or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or diluent.
A pharmaceutical composition for use in increasing brain levels of GABA comprising an effective amount of 3-amino-3-difluoromethylpropionic acid or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier or diluent.
A method of inhibiting .gamma.-aminobutyric acid transaminase in a patient in need thereof which comprises administering to said patient an effective .gamma.-aminobutyric acid transaminase inhibiting amount of 3-amino-3-fluoromethylpropionic acid or 3-amino-3-difluoromethylpropionic acid, or a pharmaceutically acceptable salt thereof.
A method of treating a patient having a disorder of the central nervous system function characterized in a low level of brain .gamma.-aminobutyric acid which comprises administering an effective .gamma.-aminobutyric acid transaminase inhibiting amount of 3-amino-3-fluoromethylpropionic acid or 3-amino-3-difluoromethylpropionic acid, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.