US 4,375,433 AGranted

Process for the preparation of 6-hydroxymethyl-2-(.beta.-aminoethylthio)-1-carbadethiapen-2-em-3-carbox ylic acid

AssigneeMerck & Co., Inc.

InventorsDavid G. Melillo, Kenneth M. Ryan

Life of this patent

Estimating the term…

Abstract

Disclosed is a process for preparing the antibiotic 6-hydroxymethyl-2-(.beta.-aminoethylthio)-1-carbadethiapen-2-em-3-carboxyl ic acid (I) ##STR1## and its pharmaceutically acceptable salt and ester derivatives. An intermediate for the production of these compounds are compounds of the formula ##STR2## wherein R.sup.5 and R are readily removable protecting groups.

Claims1

Dependent claims

The compound:

##STR31## wherein R.sup.5 and R are readily removable protecting groups.

Dependencies are inferred from the claim text.

Facts

Application: 06/186,778Filed 12 Sep 1980 · division
Priority: 23 Oct 1978
Granted: 1 Mar 1983
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07D 487/04
In which the condensed system contains two hetero rings: ortho-condensed systems
C07C 271/22
With the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms: to carbon atoms of hydrocarbon radicals…
C07D 207/16
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
C07D 207/24
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…

Family

Serial953,819Parent of this continuation-in-part · filed 23 Oct 1978
Serial63,490Parent of this division · filed 8 Aug 1979
US 4,252,722 AParent of this division
US 4,375,433 AThis patent

From the US filing history. Foreign family members aren’t listed.

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