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US 4,374,997 AGranted
Process for the preparation of zomepirac and related compounds
AssigneeMerck & Co., Inc.
InventorsJames B. Doherty, Debra L. Allison
Life of this patent
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Abstract
Zomepirac and its analogs have been prepared from a 5-aroyl-3-hydroxycarbonyl-4-substituted pyrrole-2-acetic acid via acidic decarboxylation.
Claims9
A process for preparing Zomepirac and its analogs of the structural formula:
- ##STR8## wherein Ar is phenyl or halophenyl;
- R.sup.1 and R.sup.3 independently are H or C.sub.1-6 alkyl and R.sup.2 is H, C.sub.1-6 alkyl or halo comprising decarboxylating a diacid derivative of the structural formula:
- ##STR9## wherein R.sup.1, R.sup.2 and R.sup.3 are as previously defined;
- and R is H, t-butyl, or benzhydryl in an acid or in an inert solvent containing the acid.
1 more element
Dependencies are inferred from the claim text.