Process for the production of tryptophane-hydantoin
AssigneeDegussa AG
InventorsAxel Kleemann, Marc Samson
Life of this patent
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Abstract
Tryptophane hydantoin is prepared by (a) reacting a compound of the general formula ##STR1## where A is an alkylene group having 2 or 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups in aqueous or aqueous alcoholic solution with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and (b) reacting the reaction mixture obtained with phenyl hydrazine at a pH between 0.1 and 4.
Claims10
A process of preparing tryptophane hydantoin comprising (a) reacting a compound of formula ##STR5## where A is an alkylene group having 2 or 3 carbon atoms or such an alkylene group substituted by 1 to 2 methyl groups in aqueous or aqueous-alcoholic solution with hydrogen cyanide or a cyanide ion supplying compound, ammonia or an ammonium ion supplying compound and carbon dioxide or a carbonate ion supplying compound and
- (b) reacting the reaction mixture obtained with phenyl hydrazine at a pH between 0.1 and 4.
A process according to claim l wherein the compound of formula (I) is 2(2'-formylethyl)-1,3-dioxolane, 2-(2'-formylethyl)-4-methyl-1,3-dioxolane, 2,(2'-formylethyl)-4,5-dimethyl -1,3-dioxolane, 2-(2'-formylethyl)-1,3-dioxane, 2-(2'-formylethyl)-4-methyl-1,3-dioxane or 2-(2'-formylethyl)-5,5-dimethyl-1,3-dioxane, the hydrogen cyanide or cyanide ion supplying compound is hydrocyanic acid, the ammonia or ammonium ion supplying compound is ammonia itself or ammonium carbonate and the carbon dioxide or carbonate ion supplying compound is carbon dioxide itself or ammonium carbonate.
Dependencies are inferred from the claim text.