Process for the preparation of the sulfate salt of 2-amino-5-alkylthio-1,3,4-thiadiazoles
AssigneeEastman Kodak Company
InventorKim S. Chamberlin
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Abstract
Disclosed is a novel process for the preparation of the sulfate salt of 2-amino-5-alkylthio-1,3,4-thiadiazoles, which comprises reacting 2,5-dithiobiurea with a dialkylsulfate. Derivatives of compounds produced by this novel process are useful as chemical synthetic intermediates in the preparation of organic dyes and pharmaceuticals.
Claims8
Process for the preparation of a sulfate salt of a 2-amino-5-alkylthio-1,3,4-thiadiazole, which comprises adding a dialkylsulfate to a mixture of 2,5-dithiobiurea and water.
Process for the preparation of the sulfate salt of 2-amino-5-methylthio or ethylthio 1,3,4-thiadiazole which comprises adding dimethyl or diethylsulfate to a mixture of 2,5-dithiobiurea and water, wherein (1) the mole ratio of dimethyl or diethylsulfate to 2,5-dithiobiurea is about 2.0-2.5:1, (2) the weight ratio of water to 2,5-dithiobiurea is about 1.0-3.0:1, and (3) dimethyl or diethylsulfate is added to the mixture of 2,5-dithiobiurea and water at a rate which will achieve maximum product formation.
Dependencies are inferred from the claim text.