Certain arylaliphaticthio-pyridine type compounds
AssigneeJohn Wyeth & Brother Limited
InventorRoger Crossley
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Abstract
The invention concerns the treatment of ulcers and hypersecretion in a mammal using compounds of the formula I Ar-A-S-Y I where Ar is phenyl, which may be substituted or cycloalkyl of 5 to 7 carbon atoms, A is saturated or unsaturated lower alkylene which may be substituted by lower alkyl, oxo or hydroxy, S is sulphur and Y is an optionally substituted pyridine, pyridinium, tetrahydropyridine or tetrahydropyridinium radical. Certain novel compounds and pharmaceutical compositions are also claimed.
Claims4
A compound of formula:
- ##STR3## wherein A represents saturated or unsaturated alkylene radical having from 1 to 6 carbon atoms, which may be substituted by lower alkyl of 1 to 6 carbon atoms, oxo or hydroxy, S is sulphur and Y is a radical of formula:
- ##STR4## wherein R.sup.1 is hydroxyloweralkyl, loweralkoxyloweralkyl, formyl or acetal, CH(OR.sup.4).sub.2 where R.sup.4 is lower alkyl or two R.sup.4 radicals are joined to form a lower alkylene chain, m is 1 or 2, R is lower alkyl of 1 to 4 carbon atoms or aralkyl of 7 to 12 carbon atoms, and Z.sup.- is a pharmaceutically acceptable anion, or a pharmaceutically acceptable acid addition salt of a compound containing a radical of formula IV or IIa.
2-Benzylthio-3-formyl-1-methylpyridinium bromide.
2-Benzylthio-3-hydroxymethyl-1-phenylpyridinium bromide.
2-Benzylthio-3-(diethoxy)methyl-1-phenylpyridinium chloride.
Dependencies are inferred from the claim text.