3'-Deamino-3'-morpholino carminomycin
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Tomio Takeuchi, Kuniaki Tatsuta, Yoshikazu Takahashi
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Abstract
Disclosed is 3'-deamino-3'-morpholino-carminomycin, a new anthracycline glycoside having both antimicrobial and antitumor activity. Also disclosed is a new N-alkylation procedure for preparing the above compound as well as the known anthracyclines, 3'-deamino-3'-morpholino-adriamycin and 3'-deamino-3'-morpholino-daunomycin, in high yield.
Claims2
The anthracycline glycoside 3'-deamino-3'-morpholino-carminomycin of the formula ##STR17## or a pharmaceutically acceptable acid addition salt thereof.
A process for preparing an anthracycline glycoside of the formula ##STR18## wherein R.sup.1 represents H of CH.sub.3 and R.sup.2 represents H or OH, provided that when R.sup.1 is H, R.sup.2 is H, or an acid addition salt thereof, which process comprises reacting a compound of the formula ##STR19## wherein R.sup.1 and R.sup.2 are as defined above, or an acid addition salt thereof, with a compound of the formula ##STR20## wherein X represents Br or I.
Dependencies are inferred from the claim text.