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US 4,374,847 AGranted
1-Carboxyalkanoylindoline-2-carboxylic acids
AssigneeCiba-Geigy Corporation
InventorNorbert Gruenfeld
Life of this patent
Estimating the term…
Abstract
1-Carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acids, e.g., those of the formula ##STR1## R=H, alkyl, alkoxy, halogeno or CF.sub.3 ; R'=H or R-phenyl; m=0 or 1; p,q=0 to 2; and functional derivatives thereof, are antihypertensive and cardioactive agents.
Claims17
A 1-carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acid compound of the formula:
- ##STR17## wherein Ph is unsubstituted 1,2-phenylene, or 1,2-phenylene substituted by one to three identical or different members selected from lower alkyl, lower alkoxy, lower alkylenedioxy, hydroxy, halogeno and trifluoromethyl;
- R.sub.o is hydrogen or HPh;
- each of R.sub.1, R.sub.2 and R.sub.3 is hydrogen or lower alkyl;
- and n is an integer from 2 to 8;
- an amide, mono- or di-lower alkylamide, lower alkyl ester, (amino, mono- or di-lower alkylamino, carboxy or lower carbalkoxy)-lower alkyl ester, or a pharmaceutically acceptable salt thereof.
2 more elements
1-(2,4-dimethyl-4-carboxybutanoyl)-indoline-2S-carboxylic acid;
- or a pharmaceutically acceptable alkali metal or ammonium salt thereof.
1-[4-carboxy-4-(2-phenethyl)-butanoyl]-indoline-2S-carboxylic acid;
- or a pharmaceutically acceptable metal or ammonium salt thereof.
Dependencies are inferred from the claim text.