Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines
AssigneeMerck & Co., Inc.
InventorsPaul S. Anderson, Marcia E. Christy, Ben E. Evans, David C. Remy
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Abstract
Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease.
Claims4
A method of treating anxiety, depression, muscle spasm, convulsions, mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders comprising administering to a patient in need of such treatment an effective amount of a compound of structural formula:
- ##STR144## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or C.sub.1-3 alkyl;
- R.sup.2 is C.sub.1-3 alkyl, and R.sup.1, R.sup.3 and R.sup.4 are all hydrogen.
A pharmaceutical composition useful as an anxiolytic, antidepressant, anticonvulsant, muscle relaxant, or in the treatment of mixed anxiety-depression, minimal brain dysfunction or extrapyramidal disorders comprising a pharmaceutical carrier and an effective amount of a compound of structural formula:
- ##STR145## or a pharmaceutically acceptable salt thereof, wherein R is hydrogen or C.sub.1-3 alkyl;
- R.sup.2 is C.sub.1-3 alkyl, and R.sup.1, R.sup.3 and R.sup.4 are all hydrogen.
Dependencies are inferred from the claim text.