Method and apparatus for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter
AssigneeBaxter Travenol Laboratories, Inc.
InventorsRichard I. Brown, Arnold C. Bilstad
Life of this patent
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Abstract
A method and apparatus are described for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter having a blood inlet, a blood outlet, a plasma outlet, outer members and a pair of spaced microporous filter membranes defining a blood flow path. A holder is provided for the filter having means for applying pressure against the outer members. The blood pressure at the blood inlet is sensed during plasmapheresis and variable amounts of pressure are applied against the outer members at an angular direction with respect to the membranes. In this manner, the blood flow path gap between the membranes is controlled in accordance with a desired blood pressure adjacent the blood inlet.
Claims9
A method for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter having a pair of spaced microporous filter membranes defining therebetween a blood flow path which has spaced inlet and outlet ends and which expands in cross section during blood flow therethrough, which method comprises the steps of:
- establishing a flow of blood between the inlet and outlet ends of the blood flow path,
- applying pressure against and at substantially a perpendicular direction with respect to the membranes essentially along the entire axial length of the blood flow path between the inlet and outlet ends thereof to establish the spacing between the membranes to develop at the inlet end of the blood flow path a blood pressure preselected to achieve a desired transmembrane pressure, and
- continuously maintaining the pressure essentially along the entire axial length of the blood flow path to prevent a subsequent expansion of the blood flow path in cross section during the plasmapheresis procedure and to thereby maintain the desired blood inlet pressure.
Apparatus for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter having a pair of substantially parallel, spaced microporous filter membrane defining a blood flow path therebetween, a blood inlet and a blood outlet longitudinally spaced along and communicating with the flow path, a plasma outlet, and first and second generally flexible outer members extending outwardly of and generally parallel to the membranes to sandwich the membranes therebetween, said apparatus comprising:
- a housing for receiving the filter and comprising a first panel including means for supporting the first generally flexible outer member essentially along the entire axial length of the blood flow path when the filter is received in said housing and a second panel coupled to said first panel and facing the second generally flexible outer member when the filter is received in said housing;
- said second panel including means for selectively applying pressure against the second generally flexible outer member essentially along the entire axial length of the blood flow path to urge the second generally flexible outer member toward the first generally flexible outer member supported by said first panel and establish and thereafter maintain the desired spacing between the membranes,
- whereby a desired blood pressure can be achieved and maintained at the blood inlet of the filter to obtain the desired rate of plasma collection during the plasmapheresis procedure.
Dependencies are inferred from the claim text.