Method of forming a hydrophilic coating on a substrate
AssigneeInternational Silicone Corporation
InventorR. Alastair Winn
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Abstract
A method of forming a hydrophlic coating on a substrate comprised of applying a hydrophilic copolymer capable of chemically reacting with a coupling agent which will promote adhesion to the substrate. A polyisocyanate coupling agent is applied to the surface from a solvent solution followed by applying the hydrophilic copolymer from solvent solution. In certain instances, the copolymer and isocyanate can be simultaneously applied from a solvent solution. The resulting hydrophilic coating is thrombo resistant, biocompatable and stable.
Claims56
The method of bonding a hydrophilic coating to the surface of a biomedical substrate comprising:
- applying a coating from a solvent solution comprised of a polyisocyanate to the surface of said substrate to form a coupling coating with unreacted isocyanates;
- applying a solvent solution comprised of a hydrophilic copolymer made from monomers of vinylpyrollidone and monomers containing active hydrogen which will react with isocyanate to form a covalent bond between said coupling coating and said hydrophilic copolymer;
- evaporating the solvent and reacting said isocyanates.
A method of forming a hydrophilic layer on a substrate comprising:
- forming unreacted isocyanate groups on the surface of the substrate;
- treating the surface of the substrate with a hydrophilic copolymer made from monomers of vinylpyrollidone and monomers containing active hydrogen adapted to form covalent bonds with the unreacted isocyanate.
A biomedical product having a hydrophilic coating comprising;
- a substrate;
- a polyisocyanate coupling coating;
- a hydrophilic copolymer coating made from monomers of vinylpyrollidone and monomers containing active hydrogen;
- coating retention means for retaining said hydrophilic copolymer coating on said substrate by a covalent bond, said hydrophilic copolymer having an average of at least two or more sites capable of covalently bonding to said polyisocyanate coupling coating.
Dependencies are inferred from the claim text.