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US 4,372,947 AGranted
Antibiotic saframycin S and process for producing the same
AssigneeTadashi Arai
InventorsTadashi Arai, Katsuhiro Takahashi, Kimiko Ishiguro, Koji Yokoyama
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Abstract
Antibiotic substance named saframycin S having antibacterial activities and produced by decyanating antibiotic saframycin A or cultivating Streptomyces lavendulae strain No. 314 and recovering saframycin S from a cultured broth.
Claims2
An antibiotic substance, saframycin S, having the following physico-chemical characteristics:
- color and appearance:
- dark yellow powder;
- melting point:
- 107.degree.-115.degree. C.;
- specific rotation:
- [.alpha]sub.D.sup.25 =+32.5 (0.5 methanol);
- elementary analysis:
- C:
- 61.09%, H:
- 6.67%, N:
- 7.49%
- C:
- 61.45%, H:
- 6.18%, N:
- 7.48%
- molecular weight:
- 553;
- empirical formula:
- C.sub.28 H.sub.30 N.sub.3 O.sub.8.sup.+.OH.sup.-
- ultraviolet absorption spectrum as shown in FIG. 1:
- UV .lambda..sub.max.sup.MeOH nm (log .epsilon.):
- 268 (4.21)
- UV .lambda..sub.min.sup.MeOH nm (log .epsilon.):
- 234 (3.92);
- infrared absorption spectrum as shown in FIG. 2:
- IR .sub.max.sup.CHCl.sbsp.3 cm.sup.-1 :
- 3400, 1720, 1680, 1650
- NMR spectrum (C.sub.6 D.sub.5 N) as shown in FIG. 3:
- .delta.:
- 1.88 (3H, s), 2.30 (3H, s),
- 2.48 (3H, s), 2.72 (3H, s),
- 3.82 (3H, s), 3.85 (3H, s),
- 5.46 (1H, s).
- or a pharmaceutically acceptable acid addition salt thereof.
31 more elements
Dependencies are inferred from the claim text.