Process for the preparation of cycloalkylidenemethylphenylacetic acid derivatives
AssigneeSankyo Company, Limited
InventorsAtsusuke Terada, Shigeru Tanaka, Eiichi Misaka
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Abstract
Novel 4-(2-oxo-1-cycloalkylidenemethyl)phenylacetic acid derivatives and non-toxic pharmaceutically acceptable salts thereof are useful as anti-inflammatory agents. The compounds may be prepared by reacting a p-formylphenylacetic acid ester derivative with an enamine of cycloalkanone and hydrolyzing the resulting product, or with a cycloalkanone in the presence of a base.
Claims14
A process for the preparation of a compound having the formula ##STR7## wherein R.sup.1 is an alkyl group having from 1 to 4 carbon atoms, R.sup.2 is hydrogen or an alkyl group having from 1 to 4 carbon atoms, and n is an integer from 1 to 3, which comprises reacting a compound having the formula ##STR8## wherein R.sup.1 is as defined above and R.sup.3 represents a lower alkyl group with a compound having the formula ##STR9## wherein R.sup.4 and R.sup.5 represent a lower alkyl group or, together with the nitrogen atom to which they are attached, may jointly form a cyclic amino group optionally having a ring oxygen atom and n is as defined above to produce a compound having the formula ##STR10## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5 and n are as defined above and hydrolyzing said compound (IV) to produce said compound of the formula (I).
Dependencies are inferred from the claim text.