US 4,365,075 AGranted

.omega.-Aryl-PGD compounds

AssigneeThe Upjohn Company

InventorDouglas R. Morton, Jr.

Life of this patent

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Abstract

Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.

Claims142

Dependent claims

A prostaglandin analog of the formula ##STR2## wherein D is ##STR3## wherein Y is cis-CH.dbd.CH--, trans-CH.dbd.CH--, or --CH.sub.2 CH.sub.2 --;

wherein Z.sub.1 is
1. cis-CH.dbd.CH--CH.sub.2 --(CH.sub.2).sub.g --CF.sub.2 --,
2.

Dependencies are inferred from the claim text.

Facts

Application: 05/756,100Filed 30 Dec 1976 · division
Priority: 17 Sep 1975
Granted: 21 Dec 1982
Term ends: Not estimatedThe source records don’t support an estimate.

Classification14 codes

C07D 263/04
Not condensed with other rings: having no double bonds between ring members or between ring members and non-ring members
C07C 53/21
Acids containing three or more carbon atoms: containing fluorine
C07C 405/00
Compounds containing a five-membered ring having two side-chains in ortho position to
C07C 405/0025
Analogues having the carboxyl group in the side-chains replaced by other functional groups: containing keto groups

Family

Serial614,242Parent of this division · filed 17 Sep 1975
US 4,016,184 AParent of this division · filed 5 Apr 1977
US 4,365,075 AThis patent

From the US filing history. Foreign family members aren’t listed.

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