Antihypertensive agents
AssigneeAmerican Home Products Corporation
InventorsTheodore S. Sulkowski, James L. Bergey, Albert A. Mascitti
Life of this patent
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Abstract
1,4,5,6,7,8-Hexahydro-2-alkyl-4-pentafluorophenyl-5-oxo-1,7-naphthyridine-3 -carboxylic acid esters and pharmaceutically acceptable salts thereof are useful antihypertensive agents.
Claims4
A compound of the formula:
- ##STR6## in which R is hydrogen, alkyl of 1 to 6 carbon atoms or benzyl;
- R.sup.2 is alkyl of 1 to 6 carbon atoms;
- and
- R.sup.3 is alkyl of 1 to 6 carbon atoms, alkoxyalkyl in which each alkyl moiety has 1 to 6 carbon atoms, --CH.sub.2 CF.sub.3, --CH.sub.2 CH.sub.2 CF.sub.3 or ##STR7## where R.sup.4 is hydrogen or alkyl of 1 to 6 carbon atoms and R.sup.5 is alkyl of 1 to 6 carbon atoms or arylalkyl of 7 to 10 carbon atoms and R.sup.4 and R.sup.5 taken with the nitrogen atom to which they are attached form a pyrrolidinyl, imidazolidinyl, piperidinyl, piperazinyl, 4-alkylpiperazinyl in which the alkyl group contains from 1 to 6 carbon atoms or morpholinyl heterocycle,
- and n is one of the integers 0, 1 or 2;
- or a pharmaceutically acceptable salt thereof.
The compound which is 1,4,5,6,7,8-hexahydro-2,7-dimethyl-4-(2,3,4,5,6-pentafluorophenyl)-5-oxo-1 ,7-naphthyridine-3-carboxlyic acid methyl ester.
The compound which is 1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-4-(2,3,4,5,6-pentafluorophenyl)-7-phe nylmethyl-1,7-naphthyridine-3-carboxylic acid methyl ester.
The compound which is 1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-4-(2,3,4,5,6-pentafluorophenyl)-1,7-n aphthyridine-3-carboxylic acid methyl ester.
Dependencies are inferred from the claim text.