Bis-esters of alkanediols as antibacterial agents
AssigneePfizer Inc.
InventorWayne E. Barth
Life of this patent
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Abstract
6-Acylaminopenicillanoyloxymethyl esters and 1-(6-acylaminopenicillanoyloxy)ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful as antibacterial agents. The 6-aminopenicillanoyloxymethyl ester, the 1-(6-aminopenicillanoyloxy)ethyl ester and certain other mono-substituted methyl and ethyl esters of 2-beta-acetoxymethyl-2-alpha-methyl-(5R)penam-3-alpha-carboxylic acid 1,1-dioxide are useful intermediates to the aforesaid antibacterial agents.
Claims9
A compound of the formula ##STR12## and the pharmaceutically-acceptable salts thereof, wherein R.sup.1 is selected from the group consisting of 2-phenylacetyl, 2-phenoxyacetyl, 2-amino-2-phenylacetyl, 2-amino-2-[4-hydroxyphenyl]acetyl and 2-carboxy-2-phenylacetyl;
- and Q is selected from the group consisting of hydrogen and methyl.
A method of treating a bacterial infection in a mammalian subject, which comprises administering thereto, either orally or parenterally, an antibacterially effective amount of a compound of the formula ##STR13## or a pharmaceutically-acceptable salt thereof, wherein R.sup.1 is selected from the group consisting of 2-phenylacetyl, 2-phenoxyacetyl, 2-amino-2-phenylacetyl, 2-amino-2-[4-hydroxyphenyl]acetyl and 2-carboxy-2-phenylacetyl;
- and Q is selected from the group consisting of hydrogen and methyl.
A pharmaceutical composition suitable for treating a bacterial infection in a mammalian subject, which comprises a pharmaceutically-acceptable carrier and an antibacterially effective amount of a compound of the formula ##STR14## or a pharmaceutically-acceptable salt thereof, wherein R.sup.1 is selected from the group consisting of 2-phenylacetyl, 2-phenoxyacetyl, 2-amino-2-phenylacetyl, 2-amino-2-[4-hydroxyphenyl]acetyl and 2-carboxy-2-phenylacetyl;
- and Q is selected from the group consisting of hydrogen and methyl.
Dependencies are inferred from the claim text.