2-0- and 5-0-Substituted 1.4;3.6-dianhydrohexitol mononitrates and pharmaceutical composition
AssigneeFirma Willmar Schwabe
InventorsKlaus Klessing, Shyam S. Chatterjee
Life of this patent
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Abstract
2-0- and 5-0-substituted 1.4;3.6-dianhydrohexitol mononitrates of the general formula I, ##STR1## wherein R is a halogen-substituted phenyl group, a methanesulphonyl or nicotinoyl group, as well as their physiologically acceptable acid-addition salts, insofar as R signifies the nicotinoyl group. Processes for the preparation of said compounds and pharmaceutical compositions containing said compounds.
Claims14
2-O- and 5-O-substituted 1.4;3.6-Dianhydrohexitol mononitrates of the general formula I, ##STR10## wherein R is a halogen-substituted phenyl group, a methanesulphonyl or nicotinoyl group, as well as their physiologically acceptable acid-addition salts, insofar as R signifies the nicotinoyl group.
5-O-(4-Chlorophenyl)-1.4;3.6-dianhydro-L-iditol 2-nitrate.
1.4;3.6-Dianhydro-L-iditol 2-nitrate 5-nicotinate.
1.4;3.6-Dianhydro-D-glucitol 2-nitrate 5-methanesulphonate.
1.4;3.6-Dianhydro-D-glucitol 2-nitrate 5-nicotinate.
1.4;3.6-Dianhydro-D-glucitol 2-nicotinate 5-nitrate.
1.4;3.6-Dianhydro-D-mannitol 2-nitrate 5-nicotinate.
1.4;3.6-Dianhydro-D-mannitol 2-nitrate 5-methanesulphonate.
Dependencies are inferred from the claim text.